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Baltimore Ravens at Cincinnati Bengals (+1)
Why Ravens cover: Their defense dominated in Week 1 holding Mark Sanchez to 74 passing yards while Cincinnati's was terrible, giving up 38 points to the Patriots.
Why Bengals cover: Ravens are 3-8 ATS in their last 11 meetings and 1-4 ATS in their last five trips to Cincinnati.
Total (40): Under is 4-1 in the last five meetings.
Miami Dolphins at Minnesota Vikings (-5.5)
Why Dolphins cover: Their solid defense and aggressive rushing attack take control of the tempo of games and keep opposing offenses off the field.
Why Vikings cover: Brett Favre had a 120.7 passer rating in home games last year, helping the Vikings go undefeated at the Metrodome.
Total (39.5): Under is 5-1 in the Vikings' last six home games.
Chicago Bears at Dallas Cowboys (-9)
Why Bears cover: Matt Forte (201 total yards, 2 TDs last week) seems to have taken on the Marshall Faulk role in Mike Martz's offense. Their defense held the Lions to 168 yards, while forcing three turnovers and notching two sacks.
Why Cowboys cover: Home team is 4-1 ATS in their last five meetings. Their offensive line could get a big boost with the returns of right tackle Marc Colombo and left guard Kyle Kosier.
Total (40.5): Under is 4-1 in the last five meetings.
Philadelphia Eagles at Detroit Lions (+5.5)
Why Eagles cover: They're 4-0 ATS in the last four meetings. Shaun Hill will replace the injured Matthew Stafford at quarterback for Detroit. Michael Vick looked good in place of injured Kevin Kolb.
Why Lions cover: Their new-look defense forced four fumbles against the Bears in Week 1 while Philadelphia had trouble holding on to the ball, fumbling three times vs. GB.
Total (41): With both teams using back-up quarterbacks, expect a heavy dose of the ground game.
Arizona Cardinals at Atlanta Falcons (-6.5)
Why Cardinals cover: Beanie Wells is expected to suit up after missing last week's contest.
Why Falcons cover: Matt Ryan is 13-1 straight up at home throughout his career. Arizona lost in each of its last four visits to Atlanta.
Total (43): Over is 7-1 in the last eight meetings.
Kansas City Chiefs at Cleveland Browns (-1)
Why Chiefs cover: Jake Delhomme was his usual unspectacular self last week, completing only 54 percent of his passes and throwing two interceptions. This week he has an ankle injury to contend with.
Why Browns cover: Matt Cassel has yet to prove that he is the go-to-guy at quarterback for the Chiefs. RB Jerome Harrison racked up 286 yards rushing last year vs. Kansas City.
Total (38.5): Over is 4-0 in the last four meetings.
Buffalo Bills at Green Bay Packers (-13)
Why Bills cover: Green Bay will be without leading rusher Ryan Grant (ankle) who was lost for the season last week.
Why Packers cover: Buffalo's offense (166 yards) could not move that ball through the air or on the ground in the team’s opener against Miami. Green Bay's defense forced three fumbles and accumulated five sacks versus Philadelphia.
Total (43): The Bills struggle to score and Green bay has a good defense.
Pittsburgh Steelers at Tennessee Titans (-5)
Why Steelers cover: Underdog is 6-1 ATS in the last seven meetings. Chris Johnson could struggle against a Pittsburgh defense that has held him to under 70 yards rushing in both previous meetings, and limited Michael Turner to 42 yards last week.
Why Titans cover: The Steelers are banged up on both sides of the ball with nose tackle Casey Hampton (hamstring) and left tackle Max Starks (ankle) possibly out.
Total (37): Over is 6-2 in the last eight meetings and 4-0 in the last four meetings in Tennessee.
Tampa Bay Buccaneers at Carolina Panthers ()
Why Buccaneers cover: Panthers QB Matt Moore suffered a concussion last week against the Giants and will have to be medically cleared before he can play Sunday. Rookie Jimmy Clausen will start if Moore can't go.
Why Panthers cover: Buccaneers are 1-4 ATS in their last five games vs. the Panthers and 2-7 ATS in their last nine trips to Carolina.
Total (): Under is 5-1 in the last six meetings in Carolina.
St. Louis Rams at Oakland Raiders (-3.5)
Why Rams cover: Oakland’s offensive line had trouble protecting the quarterback in the opening weekend allowing four sacks while the Raiders’ defensive line gave up 205 yards rushing.
Why Raiders cover: Sam Bradford had 55 pass attempts and three interceptions last week. That's just too much to ask from a first year quarterback, especially when you have Steven Jackson to lean on in the backfield.
Total (37.5): Bradford will have a hard time against Nnamdi Asomugha and the Raiders pass defense. Points could be at premium.
Seattle Seahawks at Denver Broncos (-3.5)
Why Seahawks cover: Denver's offensive line has struggled to protect Kyle Orton while Seattle's already charged defense will welcome linebacker Leroy Hill back from suspension.
Why Broncos cover: The Seahawks are 1-8 ATS in their last nine road games and 0-6 ATS in their last six games on grass.
Total (40): Over is 5-2 in the last seven meetings and 5-1 in the last six stays in Denver.
Houston Texans at Washington Redskins (+2.5)
Why Texans cover: Matt Schaub only attempted 17 passes in Week 1 because Arian Foster (231 yards rushing, 3 TDs) tore up a Colts defense that was focused on stopping the pass. The Texans will be hard to defend this season if Foster can continue to keep opposing defenses honest.
Why Redskins cover: They have won both prior meetings with Houston by a total of 16-points each time.
Total (43.5): Under is 9-1-1 in the Texans' last 11 road games and 12-4 in the Redskins' last 16 home games.
Jacksonville Jaguars at San Diego Chargers (-
Why Jaguars cover: San Diego's offense - without LT Marcus McNeill and WR Vincent Jackson, sputtered last week against the lowly Chiefs.
Why Chargers cover: The Jags’ offense doesn't have the big play ability to match up with San Diego if Jacksonville are forced to come from behind.
Total (45.5): Until San Diego fills the holes on its offense, don't expect big numbers like in previous years.
New England Patriots at New York Jets (+1)
Why Patriots cover: They're 10-4-1 ATS in their last 15 meetings vs. the Jets and 10-1 ATS in their last 11 games in New York vs. Gang Green. Road team is 19-7-1 ATS in their last 27 meetings. New York is without defensive tackle Kris Jenkins who is gone for the season with a torn ACL.
Why Jets cover: LaDainian Tomlinson averages over 108 rush yards in five career games against New England and is expected to be a bigger part of the offense in Week 2. Darrelle Revis held Randy Moss to just 58 yards and a touchdown in two meetings last year.
Total (38): Under is 3-1-1 in the last five meetings.
New York Giants at Indianapolis Colts (-5)
Why Giants cover: Indianapolis safety Bob Sanders (biceps) is injured again and their run defense is just not the same without him. Ahmad Bradshaw and Brandon Jacobs could have a field day, like Arian Foster.
Why Colts cover: New York's rookie punter Matt Dodge struggled in his debut. If he can't pin the Colts in their own zone, Peyton Manning and company could put up points in bunches.
Total (48): These teams could blow up the scoreboard, especially with family bragging rights on the line.
New Orleans Saints at San Francisco 49ers (+5)
Why Saints cover: They're 10-2 ATS in their last 12 meetings and 5-0 ATS in their last five meetings in San Francisco. Favorite is 5-1 ATS in the last six meetings.
Why 49ers cover: Last year's playoff hero Garrett Hartley was shaky in the opener, missing two field goals.
Total (44): Over is 3-1-1 in the last five meetings and 6-0 in the last six games in San Francisco.
Why Ravens cover: Their defense dominated in Week 1 holding Mark Sanchez to 74 passing yards while Cincinnati's was terrible, giving up 38 points to the Patriots.
Why Bengals cover: Ravens are 3-8 ATS in their last 11 meetings and 1-4 ATS in their last five trips to Cincinnati.
Total (40): Under is 4-1 in the last five meetings.
Miami Dolphins at Minnesota Vikings (-5.5)
Why Dolphins cover: Their solid defense and aggressive rushing attack take control of the tempo of games and keep opposing offenses off the field.
Why Vikings cover: Brett Favre had a 120.7 passer rating in home games last year, helping the Vikings go undefeated at the Metrodome.
Total (39.5): Under is 5-1 in the Vikings' last six home games.
Chicago Bears at Dallas Cowboys (-9)
Why Bears cover: Matt Forte (201 total yards, 2 TDs last week) seems to have taken on the Marshall Faulk role in Mike Martz's offense. Their defense held the Lions to 168 yards, while forcing three turnovers and notching two sacks.
Why Cowboys cover: Home team is 4-1 ATS in their last five meetings. Their offensive line could get a big boost with the returns of right tackle Marc Colombo and left guard Kyle Kosier.
Total (40.5): Under is 4-1 in the last five meetings.
Philadelphia Eagles at Detroit Lions (+5.5)
Why Eagles cover: They're 4-0 ATS in the last four meetings. Shaun Hill will replace the injured Matthew Stafford at quarterback for Detroit. Michael Vick looked good in place of injured Kevin Kolb.
Why Lions cover: Their new-look defense forced four fumbles against the Bears in Week 1 while Philadelphia had trouble holding on to the ball, fumbling three times vs. GB.
Total (41): With both teams using back-up quarterbacks, expect a heavy dose of the ground game.
Arizona Cardinals at Atlanta Falcons (-6.5)
Why Cardinals cover: Beanie Wells is expected to suit up after missing last week's contest.
Why Falcons cover: Matt Ryan is 13-1 straight up at home throughout his career. Arizona lost in each of its last four visits to Atlanta.
Total (43): Over is 7-1 in the last eight meetings.
Kansas City Chiefs at Cleveland Browns (-1)
Why Chiefs cover: Jake Delhomme was his usual unspectacular self last week, completing only 54 percent of his passes and throwing two interceptions. This week he has an ankle injury to contend with.
Why Browns cover: Matt Cassel has yet to prove that he is the go-to-guy at quarterback for the Chiefs. RB Jerome Harrison racked up 286 yards rushing last year vs. Kansas City.
Total (38.5): Over is 4-0 in the last four meetings.
Buffalo Bills at Green Bay Packers (-13)
Why Bills cover: Green Bay will be without leading rusher Ryan Grant (ankle) who was lost for the season last week.
Why Packers cover: Buffalo's offense (166 yards) could not move that ball through the air or on the ground in the team’s opener against Miami. Green Bay's defense forced three fumbles and accumulated five sacks versus Philadelphia.
Total (43): The Bills struggle to score and Green bay has a good defense.
Pittsburgh Steelers at Tennessee Titans (-5)
Why Steelers cover: Underdog is 6-1 ATS in the last seven meetings. Chris Johnson could struggle against a Pittsburgh defense that has held him to under 70 yards rushing in both previous meetings, and limited Michael Turner to 42 yards last week.
Why Titans cover: The Steelers are banged up on both sides of the ball with nose tackle Casey Hampton (hamstring) and left tackle Max Starks (ankle) possibly out.
Total (37): Over is 6-2 in the last eight meetings and 4-0 in the last four meetings in Tennessee.
Tampa Bay Buccaneers at Carolina Panthers ()
Why Buccaneers cover: Panthers QB Matt Moore suffered a concussion last week against the Giants and will have to be medically cleared before he can play Sunday. Rookie Jimmy Clausen will start if Moore can't go.
Why Panthers cover: Buccaneers are 1-4 ATS in their last five games vs. the Panthers and 2-7 ATS in their last nine trips to Carolina.
Total (): Under is 5-1 in the last six meetings in Carolina.
St. Louis Rams at Oakland Raiders (-3.5)
Why Rams cover: Oakland’s offensive line had trouble protecting the quarterback in the opening weekend allowing four sacks while the Raiders’ defensive line gave up 205 yards rushing.
Why Raiders cover: Sam Bradford had 55 pass attempts and three interceptions last week. That's just too much to ask from a first year quarterback, especially when you have Steven Jackson to lean on in the backfield.
Total (37.5): Bradford will have a hard time against Nnamdi Asomugha and the Raiders pass defense. Points could be at premium.
Seattle Seahawks at Denver Broncos (-3.5)
Why Seahawks cover: Denver's offensive line has struggled to protect Kyle Orton while Seattle's already charged defense will welcome linebacker Leroy Hill back from suspension.
Why Broncos cover: The Seahawks are 1-8 ATS in their last nine road games and 0-6 ATS in their last six games on grass.
Total (40): Over is 5-2 in the last seven meetings and 5-1 in the last six stays in Denver.
Houston Texans at Washington Redskins (+2.5)
Why Texans cover: Matt Schaub only attempted 17 passes in Week 1 because Arian Foster (231 yards rushing, 3 TDs) tore up a Colts defense that was focused on stopping the pass. The Texans will be hard to defend this season if Foster can continue to keep opposing defenses honest.
Why Redskins cover: They have won both prior meetings with Houston by a total of 16-points each time.
Total (43.5): Under is 9-1-1 in the Texans' last 11 road games and 12-4 in the Redskins' last 16 home games.
Jacksonville Jaguars at San Diego Chargers (-
Why Jaguars cover: San Diego's offense - without LT Marcus McNeill and WR Vincent Jackson, sputtered last week against the lowly Chiefs.
Why Chargers cover: The Jags’ offense doesn't have the big play ability to match up with San Diego if Jacksonville are forced to come from behind.
Total (45.5): Until San Diego fills the holes on its offense, don't expect big numbers like in previous years.
New England Patriots at New York Jets (+1)
Why Patriots cover: They're 10-4-1 ATS in their last 15 meetings vs. the Jets and 10-1 ATS in their last 11 games in New York vs. Gang Green. Road team is 19-7-1 ATS in their last 27 meetings. New York is without defensive tackle Kris Jenkins who is gone for the season with a torn ACL.
Why Jets cover: LaDainian Tomlinson averages over 108 rush yards in five career games against New England and is expected to be a bigger part of the offense in Week 2. Darrelle Revis held Randy Moss to just 58 yards and a touchdown in two meetings last year.
Total (38): Under is 3-1-1 in the last five meetings.
New York Giants at Indianapolis Colts (-5)
Why Giants cover: Indianapolis safety Bob Sanders (biceps) is injured again and their run defense is just not the same without him. Ahmad Bradshaw and Brandon Jacobs could have a field day, like Arian Foster.
Why Colts cover: New York's rookie punter Matt Dodge struggled in his debut. If he can't pin the Colts in their own zone, Peyton Manning and company could put up points in bunches.
Total (48): These teams could blow up the scoreboard, especially with family bragging rights on the line.
New Orleans Saints at San Francisco 49ers (+5)
Why Saints cover: They're 10-2 ATS in their last 12 meetings and 5-0 ATS in their last five meetings in San Francisco. Favorite is 5-1 ATS in the last six meetings.
Why 49ers cover: Last year's playoff hero Garrett Hartley was shaky in the opener, missing two field goals.
Total (44): Over is 3-1-1 in the last five meetings and 6-0 in the last six games in San Francisco.
